**DESCRIPTION**

CHEM 321 is designed to provide the
student with the theoretical background and practical problem solving skills
needed for quantitative chemical analyses.
The primary emphasis is on practical problem solving. A major emphasis is also placed on the
statistical treatment of experimental uncertainty. Methods for assessing the quality of data are
covered in detail and students will learn to critically analyze data.

Good problem solving skills are
essential for success in this course.
Detailed examples for the most common types of chemical analyses are
covered. Many other analyses can be
performed by similar but modified approaches, so a student should be able to
adapt the methods that have been learned to solve related problems.

**TEXT**

Daniel C. Harris, "Quantitative
Chemical Analysis", Seventh Edition, W.H. Freeman and Company (2006). textbook web page: http://bcs.whfreeman.com/qca7e/

**CLASS HOURS**

MWF 2:10 –3 :00

**OFFICE HOURS**

MWF 10-11,
3-4 T 1-2 or by appointment

Byrd Center 315 304-876-5430 ddilella@shepherd.edu

web page:
http://WEBPAGES.SHEPHERD.EDU/DDILELLA/

**PREREQUISITES**

** **Chem 207, 207L, 209, 209L. Computer skills
are not a prerequisite but students who do not know how to use a computer
spreadsheet program should see the instructor as soon as possible to get
special tutoring. With the aid of a
computer spreadsheet program, the time required to do many problems will be
significantly reduced. The textbook
gives many examples of problems that can be solved using spreadsheets.

**Homework**

Exercises and problems from the text
are assigned but will not be collected or graded. Detailed solutions to all of the exercises
are given in the text. Answers, without
details, are given for most of the problems.
The assigned problems and exercises represent a minimum that should be
attempted. You should work as many
problems as necessary until you feel comfortable with the material. The assigned problems and exercises are
excellent practice for tests.

Students are encouraged to work
together in solving these problems.

Students should use computer
spreadsheets and other calculation aids whenever possible. Many problems require considerably less work
if you use a computer spreadsheet. An
answer guide for the problems in the text is available.

**ATTENDANCE POLICY**

Students are expected to attend all
classes. Makeup exams will not be administered
without a valid written excuse. __Term
exams that are missed with a valid excuse may be made up during finals week__.

**ACADEMIC
HONESTY**

Cheating in all
its forms, including plagiarism and cheating on visual work, is considered an
academic matter and will result in automatic dismissal from the course and will
be recorded on the official transcript.

**Tests**

There will be three term tests and a
comprehensive final. There will be
several graded take-home assignments and/or in-class quizzes. Copies of previous tests are available.

**Grading**

Term tests 60%

Take Home Assignments
and in class quizzes 20%

Comprehensive Final 20%

**FINAL GRADE**

The final grade will be based on the
following scale

A 89 % to 100 % C 65
% to 76+ %

B 77 % to 88+ % D 50 % to 64+ %

**TOPICS**

*Chapter
3 (3.1-3.5) Experimental Error** –
*__3.1
Significant Figures__,
__3.2 Significant Figures in Arithmetic__, 3.3__ Significant Figures and
Graphs__, 3.4__ Types of Error__, systematic error, random error,
accuracy, precision, absolute and relative uncertainty, per cent relative
uncertainty propagation of error, 3.5__ Propagation Of Uncertainty__, Note:
Table 3-1 is an excellent summary for propagation of error, Exercises__:__
A, B Problems__:__ 1, 2, 5, 7, 10,
12, 14, 15, 20

*Chapter
4 (4.1 - 4.9) Statistics** – *__4.1 Gaussian Distribution__, mean, standard
deviation, __4.2 Confidence Intervals__, Student’s t, __4.3 Comparison Of
Means__,__4.4 – F-test__, 4.5 __t-test with spreadsheets__, __4.6 Q-test__, __4.7 Method of Least
Squares__, __4.8 -Calibration Curves__, __4.9 Spreadsheet for Least
Squares__ - __Exercises: __A,B,E,F,G __Problems:__ 1,2,8,15,16,18, 23

*Chapter
5 (5.1 - 5.4) Quality assurance and Calibration Methods - *__5.1 Basics of Quality Assurance__, __5.2
Method Validation__, __5.3 Standard Addition__, matrix effect, __5.4 Internal Standards__, response factor, __Exercises:__ A, B, C __Problems:__
6, 7,19, 22, 28, 30

*Chapter
18 (18.1 - 18.4) Spectrophotometry – *__18.1 Properties of Light__, frequency,
wavelength, photon, __18.2 Absorption of Light__, excited state, ground state, transmittance, absorbance, molar
absorptivity, Beer’s Law, __18.3 Measuring Absorbance__, __18.4 Beer’s Law
in Chemical Analysis__, __Exercises:__ A, B __Problems:__ 1,3,6,7,8,1012,16,17,18

*Chapter
6 (6.1-6.9) Chemical Equilibrium – *__6.1 The Equilibrium Constant__** , **manipulating
equilibrium constants,

*Chapter
8 (8.1- 8.4) Activity and Systematic Treatment of Equilibria - *__8.1 The Effect of Ionic Strength on
Solubility of Salts__, ionic strength, __8.2 Activity Coefficient__,
activity, mean activity coefficients, extended Debye-Huckel equation, __8.3 pH
Revisited__, __8.4 Systematic Treatment of Equilibria__, charge balance,
mass balance, 8.5 Applying Systematic Treatment of Equilibria, __Exercises:__ A,B,C,F,H __Problems:__
2,3,4,9,11,15,20

*Chapter
27 (27.1 - 27.4) Gravimetric and Combustion Analysis - *__27.1 An Example of Gravimetric
Analysis__,
__27.2 Precipitation__, crystal growth, precipitation, nucleation, colloid,
adsorption, coprecipitation, digestion, gathering, ignition, __27.3 Examples
Of Gravimetric Calculations__, __27.4 Combustion Analysis,__ __Exercises:__
A,B,C __Problems:__ 1,2,3,4,5,7,10,12

*TEST 1*

*Chapter
7 (7.1- 7.7) Let the Titrations Begin – *__7.1 Titrations__, equivalence
point, end point, titration error, indicator, standardization, primary
standard, standard solution, direct titration, back titration, __7.2 Titration
Calculations__, Kjeldahl analysis, __7.3 Spectrophotometric Titrations__, __7.4
Precipitation Titration Curve__, 7-5 __Titration of a Mixture__, __7.6
Calculating Titration Curves with a Spreadsheet__, 7.7 __End Point Detection__,
Volhard titration, Fajans titration. __Exercises:__ A, B, E, G __Problems__: 1,2,3,16,18

*Chapter
9 (9.1-9.5) Monoprotic Acid Base Equilibria – *__9-1 Strong Acids
and Bases__,
9__.2 Weak Acids and Bases__, __9.3 Weak Acid Equilibria__, fractional
dissociation, __9.4 Weak Base Equilibria__, fraction of association, __9.5
Buffers__, Henderson-Hasselbalck equation, buffer capacity, __Exercises:__
A,E,G,I __Problems:__ 1,2,4,5,6,8,9,11,18,19,21,26,28,31,34,36

*Chapter
10 (10.1-10.6) Polyprotic Acid-base Equilibria – *__10.1 Diprotic
Acids And Bases__,
acidic, basic and intermediate forms, __10.2 Diprotic Buffers__, __10.3
Polyprotic Acids And Bases__, __10.4 Which Is The Principal Species __, __10.5
Fractional Composition Diagrams__, __10-6 Isoelectronic pH, Isoionic pH__,
zwitterion. __Exercises:__ A,D __Problems:
__2, 4, 11, 15, 20, 23, 27, 36, 38

*Chapter
11 (11.1-11.8) Acid-Base Titrations – *__11.1 Titration Of Strong Acid
with Strong Base__
titration, __11.2 Titration Of A Weak Acid With Strong Base__, __11.3
Titration Of A Weak Base With Strong Acid__, __11.4 Titrations in Diprotic
Systems__, __11.5 Finding The End
Point with a pH Electrode__, derivative plots, Gran plots, __11.6 Finding
the End Point with indicators__, indicator error,__11.7 Practical Notes__,
__11.8__ __The Leveling Effect__, titrations in nonaqueous solvents, __Exercises:__ A, B, C, F __Problems:__
1,3, 5, 8,19, 25,33,36,37,41,42,43,45,54

*Chapter
12 (12.1-12.3, 12-6-12.7) EDTA Titrations - *__12.1
Metal-Chelate Complexes__, ligands, chelate effect, __12.2 EDTA__,
acid-base properties of EDTA, EDTA complexes, formation constant, conditional
formation constant, __12-3 EDTA Titration Curves__, __12.6 Metal Ion Indicators__, __12.7
EDTA Titration Techniques__, direct titration, back titration, displacement
titration, indirect titration, masking. __Exercises:__
B, C, D, E __Problems:__
1,2,3,7,26,27,28

*TEST 2*

*Chapter
14 (14.1-14.6) Fundamentals of Electrochemistry – *__14.1 Basic
Concepts__,
oxidation, reduction, oxidizing agents, reducing agents, charge, current,
voltage, electrical work, Ohm’s Law, power, __14.2 Galvanic Cells__, half
reaction, salt bridge, __14.3 Standard Potentials__, __14-4 Nernst Equation__,
calculations with the Nernst equation, Lattimer Diagrams, __14.5 E____°____ and K _{sp}__,

** Chapter
15 (15.1-15.7) Electrodes and Potentiometry – **15.1

*Chapter
16 (16.1-16.7) Redox Titrations –*__16.1 Redox Titration Curves__, __16.2 Redox End points__, __16.3
Adjustment of Analyte Oxidation State__, pre-oxidation, pre-reduction, __16.4
Oxidation With Potassium Permanganate__, __16.5 Oxidation With Cerium(IV)__,
__16.6 Oxidation __With Potassium Dichromate, __16.7 Methods Involving
Iodine__, iodimetry, iodometry, sodium thiosulfate __Exercises:__ B, D __Problems: __6,8,13,15,16,19,21,24,27

*Chapter
17 (17.1-17.3) Electroanalytical Techniques –*__17.1
Fundamentals of Electrolysis__: ohmic potential, concentration polarization__17-2
Electrogravimetric Analysis__, current-voltage behavior during electrolysis,
constant-voltage electrolysis, constant current electrolysis, controlled
potential electrolysis with a three electrode cell, __17-3 Coulometry__, coulometric titration, __Exercises:__ B __Problems:__ 1, 2,

** Chapter
23 (23.1-23.5) Introduction to Analytical Separations ** -

** Chapter
24 (24.1) Gas Chromatography**-

*Chapter
25 (25.1) High Performance Liquid Chromatography*__25-1 The
Chromatographic Process__, HPLC columns, the stationary phase, elution,
isocratic and gradient elution, solvents, __Exercises:__ A

** Chapter
26 (26.1) Chromatographic Methods and Capillary Electrophoresis- **26-1 – Ion
Exchange Chromatography

*TEST 3 – May 1, 2009*

*COMPREHENSIVE FINAL – 9:00AM, May 8, 2009*